The Thomas F. Eagleton United States Courthouse is the largest single courthouse in the United States. It is the main office of the United States District Court for the Eastern District of Missouri and the United States Court of Appeals for the Eighth Circuit. It was named after U.S. Senator Thomas F. Eagleton.
Thomas F. Eagleton United States Courthouse
111 S 10th St, St. Louis, MO 63102 Google Maps
| Number | Building | City | Floors | Height | Year |
| 1 | One Metropolitan Square | St. Louis | 42 | 181m | 1989 |
| 2 | One AT&T Center | 909 Chestnut St. St. Louis | 44 | 179m | 1986 |
| 3 | Thomas F. Eagleton Courthouse | 111 S 10th St. St. Louis | 28 | 170m | 2000 |
| 4 | US Bank Plaza | 505 N 7th St. St. Louis | 35 | 148m | 1976 |
| 5 | Laclede Gas Building | 720 Olive St. St. Louis | 31 | 122m | 1969 |
| 6 | Southwestern Bell Building | 1010 Pine St. St. Louis | 26 | 122m | 1926 |
| 7 | Civil Courts Building | 10 N Tucker Blvd. St. Louis | 13 | 118m 386Ft | 1929 |
| 8 | 100 Above the Park | 100 Kingshighway Blvd. STL | 36 | 117m | 2020 |
| 9 | Bank of America Plaza | 800 Market St. St. Louis | 31 | 117m | 1981 |
| 10 | 600 Washington | 600 Washington Ave. STL | 25 fl | 114m | 1985 |
| 11 | Park East Tower | 4909 Laclede Ave. St. Louis | 26 | 101m | 2007 |
| 12 | Queeny Tower (torn down 2021) | St. Louis | 19 | 98m | 1965 |
| 13 | One Cardinal Way | 1 Cardinal Way, St. Louis | 29 | 98m | 2020 |
| 14 | The Tower at OPOP | 411 N 8th St. St. Louis | 25 | 95m | 2010 |
| 15 | Park Plaza Apartments | 212 Kingshighway Blvd. STL | 27 | 94m | 1931 |
| 16 | 1010 Market Street | 1010 Market St. St. Louis | 20 | 90m | 1982 |
| 17 | Millennium Hotel St. Louis Tower | 200 S 4th St. St. Louis | 28 | 88m | 1968 |
| 18 | Four Seasons Hotel St. Louis | 999 N 2nd St. St. Louis | 19 | 88m | 2007 |
| 19 | The Gentry’s Landing | 400 N 4th St. St. Louis | 28 | 87m | 1965 |
| 20 | Mansion House Apartments | 300 N 4th St. St. Louis | 28 | 87m | 1965 |
